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WEDNESDAY, 16 February 2011
16.00 Registration
Welcome and Opening Session
17.00 Opening and Welcome
Jeff Cole (Chairperson of the EFB-Microbial Physiology Section)
University of Birmingham, Birmingham, UK
17.15 Keynote lecture 1: (Chair Diethard Mattanovich)
Anne Willis
University of Leicester, GB
Post-transcriptional control of gene-expression following cell stress
18.30 Welcome buffet
THURSDAY, 17 February 2011
08.30 Registration
Session 1: Quality control in RPP
Chair: Brigitte Gasser (BOKU, Vienna, Austria)
Chair: Markku Saloheimo (VTT Technical Research Centre of Finland, Finland)
09.00 Intro from Chair
09.05 Diethard Mattanovich
Department of Biotechnology, BOKU, Vienna, Austria
The stressful life of Pichia pastoris producing recombinant protein
09.35 Jan Maarten van Dijl
University of Groningen, Netherlands
Membrane protein overproduction in Bacillus
10.05 Lorna Ashton
University of Manchester, UK
A novel approach for detecting recombinant protein production using Raman and Infrared spectroscopy
10.25 Špela Peternel
National Institute of Chemistry, Ljubljana, Slovenia
Purification of active protein nanoparticles (non-classical inclusion bodies) produced in E. coli and their possible applications
10.45 Coffee Break
11.15 Wouter Vervecken
Oxyrane, Gent, Belgium
Expression of biologics in the glyco-engineered yeast Yarrowia lipolytica
11.45 Neus Ferrer-Miralles
Universitat Autònoma de Barcelona, Spain
Uncoupling proteolytic enhancement from folding modulation of chaperones in the production of recombinant proteins
12.05 Peter Neubauer
University of Technology, Berlin, Germany
Process development for oxidation sensitive proteins – the ribonuclease inhibitor case
12.25 Harald Pichler
ACIB & University of Technology, Graz, Austria
Pig liver esterase - re-introducing a valuable biocatalyst into industrial processes
12.45 Lunch and POSTER Session
Session 2: Production of multimeric proteins (sponsored by  )
Chair: Michael Sauer (BOKU, Vienna, Austria)
Chair: Michael Betenbaugh (Johns Hopkins University, Baltimore, US)
14.45 Intro from Chair
14.50 Antonio Villaverde
Universitat Autònoma de Barcelona, Spain
Bacterial production of protein nanoparticles
15.20 Wolfgang Buchinger
Boehringer Ingelheim, Vienna, Austria
RPP in bacteria vs yeast
15.50 Coffee Break
16.10 Anne B. Tolstrup
Symphogen A/S, Lyngby, Denmark
Cost-efficient development of recombinant antibody mixtures by single-batch manufacturing
16.40 Melanie Kern
University of Technology, Darmstadt, Germany
Recombinant production of multiheme cytochrome c complexes in the epsilonproteobacterium Wolinella succinogenes
17.00 Elena Garcia-Fruitos
CIBER BBN, Barcelona, Spain
Inclusion bodies: a promising alternative for tissue engineering
17.20 Chandra Gurramkonda
Institute for Technical Chemistry, Hannover, Germany
Secretory expression and high cell density cultivation of host cell receptor-binding envelope domain III of Dengue serotypes 1-4 in Pichia pastoris
17.40 Paolo Bartolini
IPEN-CNEN, University of Sao Paulo, Brasil
In Vitro, ex vivo and in vivo recombinant growth hormone synthesis for gene therapy applications
18.0 Andreas Loos
Department of Applied Genetics and Cell Biology, BOKU, Vienna, Austria
Recombinant antibodies in Arabidopsis seeds
18.20 Close
FRIDAY, 18 February 2011
Session 3: Strains and processes
Chair: Ursula Rinas (Helmholty Center for Infection Research, Braunschweig,
Germany)
Chair: Paula Alves (ITQB, Oeiras, Portugal)
09.00 Intro from Chair
09.05 Michael Rasmussen
Novozymes, Denmark
Bacillus production systems
09.35 Jesus Zurdo
Lonza, Cambridge, UK
Designing developability in biopharmaceuticals
10.05 Stephanie P. Cartwright
Aston University, Birmingham, UK
Rationalizing membrane protein production in Saccharomyces cerevisiae
10.25 Moira Monika Schuler
Dublin City University, Dublin, Ireland
Development of a general applicable feed-back strategy to control the specific growth rate of microbial cells in fed-batch cultures
10.45 Coffee Break
11.15 Jens Wölfel
CEVEC Pharmaceuticals GmbH, Cologne, Germany
CAP-Technology: Production of biopharmaceuticals in human amniocytes
11.45 Sofia Costa
IBB, University of Minho, Braga, Portugal
Evaluation of a novel Escherichia coli fusion system for overproduction of recombinant immunogenic proteins
12.05 Stefan Schönert
c-LEcta GmbH, Leipzig, Germany
c-LEcta’s Bacillus Platform: high efficient recombinant protein production
12.25 Emilio Casanova
Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna, Austria
Bacterial artificial chromosomes improve recombinant protein production in mammalian cell lines
12.45 Lunch and POSTER Session
Session 4: Metabolism and RPP(sponsored by  )
Chair: Paola Branduardi (Università degli Studi di Milano-Bicocca, Italy)
14.45 Intro from Chair
14.50 Alan Dickson
University of Manchester, UK
Metabolomics and RPP in mammalian cells
15.20 Lars M. Blank
Dortmund University, Dortmund, Germany
Pichia pastoris: metabolic consequences of recombinant protein production
15.40 Hendrik Waegeman
Gent University, Gent, Belgium
Increasing recombinant protein production in Escherichia coli K12 by increasing the biomass yield of the host cell
16.00 Coffee Break
16.30 Pau Ferrer
Universitat Autònoma de Barcelona, Spain
Energy and central metabolism interactions with RPP in yeast
17.0 Ursula Rinas
Helmholtz Center for Infection Research,
Braunschweig, Germany
Close-up views on bacterial RPP related stress responses
17.30 Julia Glazyrina
University of Technology, Berlin, Germany
High-throughput growth rate controlled fed-batch cultivations for recombinant protein production in Saccharomyces cerevisiae
17.50 Joseph Shiloach
Biotechnology Core Laboratory, NIDDK/NIH Bethesda MD, USA
The role of small RNA SgrS in controlling glucose assimilation and acetate excretion in high density growth of E. coli
18.10 Jeff Cole
University of Birmingham, UK
Generic methods for the isolation of Escherichia coli Strains for improved recombinant protein production
18.30 Open Meeting of the EFB Section on Microbial Physiology
19.30 Close
SATURDAY, 19 February 2011
09.00 Intro from Chair
09.05 Keynote lecture 2 - Chair: Jeff Cole (University of Birmingham, UK)
Randy Kaufman
University of Michigan, USA
Mammalian UPR
Session 5: Regulation of RPP
Chair: Nic Mermod (University of Lausanne, Switzerland)
Chair: Alan Dickson (University of Manchester, UK)
10.00 Intro from Chair
10.05 Niall Barron
Dublin City University, Dublin, Ireland
Micro RNAs and mammalian cell productivity
10.25 Herman Pel
DSM, Netherlands
Omics approaches for identifying bottlenecks in RPP by Aspergillus
10.45 Coffee Break
11.15 Nicole Borth
Department of Biotechnology, BOKU Vienna, Austria
A CHO cell line that grows without glutamine: transcriptomic and microRNA profiles during batch culture and effects on recombinant protein production
11.45 Laura Dato
Università degli Studi di Milano-Bicocca, Italy
The impact of oxygen on recombinant protein production: global transcriptome and proteome response in Saccharomyces cerevisiae and a comparison with the Pichia pastoris transcriptional profiles
12.05 Florian Strobl
Department of Biotechnology, BOKU, Vienna, Austria
Impact of induction strategies on recombinant E. coli bioprocesses
12.25 Bernhard Seiboth
University of Technology, Vienna, Austria
Epigenetic regulation of cellulase gene expression by Trichoderma reesei
12.45 Lunch and POSTER Session
Session 6: Protein secretion systems
Chair: Jeff Cole (Universitz of Birmingham, UK)
Chair: Luisa Tutino (Università degli Studi di Napoli - Federico II, Italy)
14.05 Intro from Chair
14.10 Arthur Ram
Leiden University, Netherlands
Cell wall and shape in RPP by Aspergillus
14.40 Nic Mermod
University of Lausanne, Lausanne, Switzerland
Protein expression using engineered mammalian cell lines and vectors
15.00 Yoshimi Kikuchi
AJINOMOTO CO., INC., Kawasaki, Japan
A novel recombinant protein secretion system using Corynebacterium glutamicum: CORYNEX®
15.20 Coffee Break
15.40 Martin Pfeffer
Department of Biotechnology, BOKU, Vienna, Austria
A kinetic model to quantify intracellular flux of a secreted antibody fragment by using a novel 34S labelling in Pichia pastoris
16.0 Jussi Joensuu
VTT Technical Research Centre of Finland, Espoo, Finland
Hydrophobin fusions for high level intracellular protein production and purification in plants and filamentous fungi
16.20 Ian Henderson
University of Birmingham, UK
Bacterial autotransporter secretion mechanisms
16.50 Poster awards, sponsored by Novozymes
17.20 Closing of the scientific programme
19.30 Conference dinner (more information here)
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About the Conference 
